Can Rejuran Skin Booster (DEP) and RF Microneedling Be Considered Together for Pores and Uneven Texture?

Quick summary: Dull, dehydrated-looking skin and visibly enlarged pores or uneven surface texture may occur at the same time, but they don’t necessarily involve the same underlying skin concerns. Where more than one concern is identified during a doctor consultation, Rejuran Skin Booster (DEP), RF Microneedling, or a combination of treatment approaches may be discussed. Whether one treatment or more than one treatment is appropriate depends on the individual’s assessment.

Rejuran Skin Booster (DEP) vs RF Microneedling: A Quick Comparison

Rejuran Skin Booster (DEP) RF Microneedling
Downtime Minimal to none Minimal to none
Who it suits best Those with skin quality concerns, dull-looking skin, or dehydration Those with enlarged pores or uneven surface texture, including post-acne texture
Pain level Minimal, non-injection delivery Mild, may be eased with numbing cream
Results-onset speed Gradually, across a series of sessions Gradually, across 3–6 sessions
Longevity Effects may be supported with periodic follow-up sessions Effects may be supported with periodic follow-up sessions
Cost per month of result Varies by number of sessions; a personalised quote is provided at consultation Varies by number of sessions; a personalised quote is provided at consultation

Disclaimer: this table is a general guide only, not a guarantee. Outcomes vary from person to person, and whether these treatments are combined depends entirely on an individual assessment by a doctor.

More Than One Skin Concern Can Be Discussed During a Consultation

People often attend a consultation with one main concern, such as dull-looking skin or visibly enlarged pores. During assessment, other skin concerns may also be identified. These concerns don’t necessarily involve the same layer of the skin or the same treatment approach.

Where more than one concern is identified, a doctor may discuss whether one treatment approach or more than one treatment category is appropriate for the individual’s skin concerns and treatment priorities.

What Role May Rejuran Skin Booster (DEP) Play Within a Treatment Plan?

Rejuran Skin Booster (DEP) (a salmon-DNA-derived skin booster) is a Korean-developed cosmetic treatment built around PDRN (Polydeoxyribonucleotide) and amino acids, delivered topically through dermo-electroporation (DEP) — a non-injection method that uses gentle electrical pulses to help the formula penetrate the skin’s surface layers. It is designed to work alongside the skin’s own surface renewal processes.

Depending on the individual’s assessment, it may be considered where concerns include:

  • Skin quality
  • Dull-looking skin
  • Dehydration
  • Overall skin radiance

Whether Rejuran Skin Booster (DEP) is appropriate depends on the individual’s skin concerns and clinical assessment.

What Role May RF Microneedling Play Within a Treatment Plan?

RF Microneedling combines microneedling with radiofrequency energy and is designed to target deeper layers of the skin, where it may support the skin’s own texture-remodelling response.

Depending on the individual’s assessment, it may be considered where concerns include:

  • Enlarged or visible pores
  • Uneven surface texture, including texture linked to past acne
  • Rough or coarse-feeling skin

Whether RF Microneedling is appropriate depends on the individual’s skin concerns and clinical assessment.

A note on scope: RF Microneedling is also sometimes discussed in the context of early fine lines and firmness loss — a different concern from pore size and surface texture, and one covered separately. This article focuses specifically on pore and texture-related concerns rather than firmness or early collagen-related fine lines.

When Might Both Treatment Approaches Be Discussed?

Where skin quality and pore or texture concerns are both identified during assessment, a doctor may discuss whether Rejuran Skin Booster (DEP) and RF Microneedling are appropriate as part of the same overall treatment plan.

This doesn’t mean both treatments are appropriate for everyone. Some people may only require one treatment approach, while others may be considered for a combination treatment plan. The decision depends on the individual’s assessment rather than a standard treatment pathway.

Combined Plan: Rejuran Skin Booster (DEP) + RF Microneedling

Rejuran Skin Booster (DEP) + RF Microneedling
Downtime Minimal to none for both
Who it suits best Those with concerns spanning both skin quality (dullness, dehydration) and pore size or surface texture
Pain level Minimal for the skin booster; mild for RF Microneedling, may be eased with numbing cream
Results-onset speed Both build gradually, across their own respective course of sessions
Longevity Both may be supported with periodic follow-up sessions
Cost per month of result Varies by number of sessions for each treatment; a personalised quote is provided at consultation

Disclaimer: this table is a general guide only, not a guarantee. Outcomes vary from person to person, and whether these treatments are combined depends entirely on an individual assessment by a doctor.

Questions About This Pairing

Can skin quality and pore or texture concerns be assessed during the same consultation?
Yes. A doctor consultation can assess multiple skin concerns during the same appointment and discuss whether one treatment approach or more than one treatment may be appropriate.
Is this the same as RF Microneedling for fine lines or firmness?
No. RF Microneedling may also be discussed for early fine lines and firmness loss in a separate context. This article focuses specifically on pore size and surface texture concerns, including texture linked to past acne, which is a distinct skin concern assessed separately during consultation.
Will everyone with skin quality concerns need RF Microneedling as well?
Not necessarily. Whether one treatment or more than one treatment approach is appropriate depends on the concerns identified during the individual’s assessment.
How may a combination treatment plan be decided?
A doctor consultation considers the individual’s skin concerns, medical history and treatment priorities before discussing whether one treatment or more than one treatment approach may be appropriate.
Can a treatment plan change over time?
Yes. Treatment plans may be reviewed over time if skin concerns or treatment priorities change. Any changes should be discussed during a doctor consultation.
What should I discuss during my consultation?
It may be helpful to discuss all of your skin concerns, even if one concern seems more noticeable than another. This can help guide the discussion about which treatment approach, if any, may be appropriate.

The Right Starting Point Is a Conversation With a Doctor

If you’ve been considering a Rejuran Skin Booster (DEP), RF Microneedling, or both, the most useful next step is a face-to-face consultation with a doctor who can assess your individual concerns and advise accordingly.

At ClearSK, our doctors take time to understand each patient’s skin condition before recommending any treatment. There is no one-size-fits-all plan – what matters is what is clinically relevant for you.

Why Patients Choose ClearSK

  • 17+ years trusted in Singapore
  • Thousands of treatments performed across our network of Singapore clinics
  • 100+ treatment selections across skin, face, body and hair growth
  • Doctor-designed protocols — treatment plans are developed and overseen by registered medical practitioners
  • Multiple clinic locations across Singapore, with consistent clinical standards at each

ClearSK offers both regenerative and texture-remodelling skin treatments, so patients weighing more than one approach can be assessed across the full range of clinically appropriate options.

Where Should You Start?

  • Mainly concerned about dullness or skin quality? A Rejuran Skin Booster (DEP) may be considered as part of a clinical discussion.
  • Mainly concerned about enlarged pores or uneven texture? RF Microneedling may be considered depending on your clinical assessment.
  • Concerns spanning both? A consultation can help determine whether a combined plan is appropriate for you.

Chat with us on WhatsApp

Important. This article is for general informational purposes only and doesn’t constitute medical advice. It does not make any claims about treatment outcomes. Results vary from person to person, and individual suitability can only be determined through a doctor consultation.

Terms of Receiving Private Information: 

By receiving our private information, you have agreed not to disclose any information received via this private communication to anyone, except for purchase evaluation or referral only. Our rights reserved.

Terms of Receiving Price Guide: 

By receiving our price guide, you have agreed not to disclose any information received via this private communication to anyone, except for purchase evaluation or referral only. Our rights reserved.

Booking Form